서지주요정보
Effects of minoxidil on immune system = Minoxidil의 생체면역계에 대한 영향
서명 / 저자 Effects of minoxidil on immune system = Minoxidil의 생체면역계에 대한 영향 / Jong-Il Kim.
저자명 Kim, Jong-Il ; 김종일
발행사항 [서울 : 한국과학기술원, 1989].
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등록번호

4105629

소장위치/청구기호

학술문화관(문화관) 보존서고

MBE 8907

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초록정보

The immunomodulation effects of minoxidil were investigated using various parameters. Minoxidil did not cause any modulation of in vitro antibody response to lipopolysaccaride(LPS), DNP-Ficoll and sheep red blood cell (SBRC). But minoxidil increased mitogen, LPS and concanavalin A (Con A), - induced lymphoproliferation at relatively low concentration and did not have any increase of phytohemagglutinin (PHA)-induced proliferative response. Meanwhile the coculture with rat hepatocytes was used to elucidate immunomodulation of metabolites minoxidil which could be produced by hepatocytes. In coculture system, minoxidil enhanced T-dependent antibody response to SRBC by dose-dependence but lost enhancing effect in in vitro mitogen - induced lymphoproliferative assay. In addition, in vivo exposure of minoxidil to mice did not caused any immunomodulation effects which were presented in vitro coculture system. These results suggest that metabolites of minoxidil have immunomodulation on T-cell specific response and minoxidil itself affect mitogen - induced proliferative response although mechanism of immunomodulation is not well-known.

서지기타정보

서지기타정보
청구기호 {MBE 8907
형태사항 vii, 53 p. : 삽도 ; 26 cm
언어 영어
일반주기 저자명의 한글표기 : 김종일
지도교수의 영문표기 : Kyu-Hwan Yang
지도교수의 한글표기 : 양규환
학위논문 학위논문(석사) - 한국과학기술원 : 생물공학과,
서지주기 Reference : p. 47-52
주제 Cell proliferation.
Cell culture.
Minoxidil.
미녹시딜. --과학기술용어시소러스
세포 증식. --과학기술용어시소러스
세포 배양. --과학기술용어시소러스
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