서지주요정보
Compressed sensing approach for fMRI and chemical exchange saturation transfer imaging in brain = 압축 센싱 기법을 이용한 뇌기능 자기공명영상과 CEST 복원 연구
서명 / 저자 Compressed sensing approach for fMRI and chemical exchange saturation transfer imaging in brain = 압축 센싱 기법을 이용한 뇌기능 자기공명영상과 CEST 복원 연구 / Ju-Young Lee.
발행사항 [대전 : 한국과학기술원, 2014].
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8026302

소장위치/청구기호

학술문화관(문화관)B1층 보존서고

MBIS 14011

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초록정보

Compressed sensing approach makes possible to accelerate data acquisitions. However, study for in vivo CS-fMRI or CS-CEST has not existed. in vivo CS-fMRI has some difficulties to apply CS, such as slow temporal dynamics of hemodynamic signals and concerns of statistical power loss. Also, CEST is a relatively new subject in MR imaging, so applying CS has not tried. In this study, we investigated the properties of CS-fMRI and CS-CEST by using k-t FOCUSS as a reconstruction algorithm. In the study of CS-fMRI, Functional sensitivity, specificity, and time course were used to measure the ability of CS-fMRI. Consequently, the CS-fMRI has following properties. 1) the Gaussian sampling pattern with fully sampled center one line and the random sampling pattern with 10\% low k-space lines are more sensitive than the complete random sampling pattern, 2) CS-fMRI with GRE improves the functional sensitivity and specificity over the fully sampled data, 3) CS-fMRI improves temporal resolution, and reduces temporal noises, 5) CS-fMRI is effective for both block-design and event-related paradigms in BOLD and cerebral blood volume-weighted contrasts. We conclude that CS-fMRI is a valuable tool especially for conventional GRE fMRI studies. In the study of CS-CEST, the validity of constructing z-spctrum from CS data was shown. As a result, the reconstruction of baseline images and z-spectrum is realizable from CS-CEST, albeit further work is required to establish the advantages of CS-CEST.

최근 샘플링 수가 부족한 데이터에서도 고해상도 영상 복원이 가능하다는 압축 센싱 이론이 등장하면서 자기 공명 영상 분야에서도 영상을 얻어내는데 걸리는 시간이 감소하였다. 이를 바탕으로 하여 자기 공명 영상의 여러 분야, 특히 동적 구조 이미징에서 다양한 복원 알고리즘들이 개발되었고, 다른 분야에서도 압축 센싱 이론을 적용하는 것의 실효성에 대한 의견이 제기되고 있다. 본 연구에서는 혈류의 변화를 이용하여 이미징하는 뇌기능 자기 공명 영상과 분자의 특성에 기인한 CEST 영상에 압축 센싱 이론을 적용해보고, 각 경우의 장단점과 압축 센싱 이론 적용의 타당성을 보이는 것을 목적으로 한다. 실제 뇌 영상을 이용한 실험 결과들은 압축 센싱을 적용할 경우 전체적으로 샘플링 했을 때보다 더 좋은 결과를 보여주고 있다.

서지기타정보

서지기타정보
청구기호 {MBIS 14011
형태사항 vi, 36 p. : 삽화 ; 30 cm
언어 영어
일반주기 저자명의 한글표기 : 이주영
지도교수의 영문표기 : Jong-Chul Ye
지도교수의 한글표기 : 예종철
학위논문 학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과,
서지주기 References : p. 32-35
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이 주제의 인기대출도서

Different sampling patterns for experiments. (A) Fully sampled (R=1), (B) undersampled along the phase encoding (PE) direction with a reduction factor (R) of2. The sampling probability follows a Gaussian distribution with sampling ofky = 0 (Gaussian) (top panel) or is constant with the sampling of6 central lines (Rand+C6) (bottom panel). (C) Same undersampling patterns as in (b) but with R of4.

Block-designed and event-related fMRI paradigms and model hemodynamic responses used in studies. The shaded rectangles are stimulation periods in S1 BOLD (a and b) and OB CBV-weighted fMRI experiments (C and d). In the rapid ER paradigm (b and d), gray and black vertical bars correspond to the two stimulus types. The curves in (a)-(c) are the assumed true hemodynamic responses in simulated fMRI da

Acquisition and experimental parameters

Statistical t-value maps of two rats responding to forepaw stimulation using experimental block-designed GRE fMRI with different sampling patterns and acceleration factors. Color functional maps were overlaid on baseline GRE images. Images were reconstructed by using k-t FOCUSS with FT and KLT. Note that the number ofspuriously activated voxels are reduced with KLT

Statistical t-value maps oftwo rats responding to amyl-acetate odor stimulation using exper- imental block-designed GRE fMRI with different sampling patterns and R of4. Color functional maps were overlaid on T2-weighted images. Images were reconstructed with k-t FOCUSS with KLT (pi 0.01, uncorrected).

Experimental statistical t-value maps oftwo rats responding to amyl acetate odor stimulation using experimental block-designed GRE fMRI with full sampling and undersampling of R of 4. Color functional maps were overlaid on T2- weighted images. The white arrows indicate areas with false activation and opposite signal change. Undersampled images were reconstructed with k-t FOCUSS with KLT.

Time courses of S1 (a) and OB (b) with the block-designed paradigm. The black lines correspond to reconstruction with KLT sparsifying transforms. Different panels correspond to different k-space sampling schemes. The yellow bars denote the stimulation period.

Temporal autocorrelation functions of the reconstructed time series with various sampling patterns and sampling rates for averaged, block-designed. GRE S1 fMRI data. Only results for k-t FOCUSS with KLT are shown here, since k-t FOCUSS with FT produced similar results.

GRE fMRI maps oftwo rats responding to ER 3 Hz and 8 Hz forepaw stimuli, obtained with full, Gaussian (R=4) and Rand+C6 (R=4) sampling patterns. Color maps were overlaid on baseline GRE images. CS images were reconstructed using k-t FOCUSS with KLT.

GRE fMRI maps of odor stimulations by amyl acetate (odor A) and pyridine (odor B) derived from (a) fully sampled rapid ER, (b) rapid ER with Rand+C6 (R=4), and (c) blockdesigned fMRI (R=4) experiments. Color maps were overlaid on T2-weighted anatomic images. CS images were reconstructed using k-t FOCUSS with KLT.

EPI-based fMRI maps oftwo rats responding to forepaw stimulation obtained from block- designed data with full, Gaussian (R=2), and Rand+C6 (R=2) sampling patterns. Color maps were overlaid on the corresponding baseline EPI images.

The principles of CEST imaging. The saturation of exchangeable solute protons is transferred to bulk water protons.

Z-spectrum(a) and MTR asymmetry(b). (a) shows the plot of relative signal intensity for the change of off resonance frequency. (b) shows the plot ofMTR asymmetry values for off resonance frequencies.

ROI for white and gray matter analysis of CEST results

Baseline images of 3D bSSFP-CEST and 3D FISP-CEST reconstructed by k-t FOCUSS: The number of slice is 8, and this figure shows only one slice.

The z-spectrum for white and gray matter regions. The red line shows the z-spectrum of image from PI, and the blue line shows the z-spectrum ofimage from reconstruction.

Magnetization Transfer Ratio for white and gray matter regions of 3D bSSFP-CEST and 3D FISP-CEST. The red line shows the MTR asymmetry ofimage from PI, and the blue line shows the MTR asymmetry ofimage from reconstruction.