서지주요정보
UVC에 의한 SK-HEPl 세포의 예정사 과정에서 p53 단백질의 안정성에 관한 연구 = Stability of p53 protein during UVC-induced apoptosis in SK-HEPl cells
서명 / 저자 UVC에 의한 SK-HEPl 세포의 예정사 과정에서 p53 단백질의 안정성에 관한 연구 = Stability of p53 protein during UVC-induced apoptosis in SK-HEPl cells / 정소영.
저자명 정소영 ; Chung, So-Young
발행사항 [대전 : 한국과학기술원, 2003].
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소장정보

등록번호

8013792

소장위치/청구기호

학술문화관(문화관) 보존서고

MBS 03023

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초록정보

The tumor suppressor, p53 is a short-lived nuclear phosphoprotein that functions as a DNA damage-inducible sequence specific transcription factor. The level of p53 protein depends on the UVC dosages during UVC-induced apoptosis in SK-HEPl cells. p53 protein exists on the high level at lower UVC dosages, but p53 protein exists on the low level at higher UVC dosages. The stability of p53 protein rapidly increases with lower UVC dosages, but the stability of p53 protein slowly increases with higher UVC dosages. The stability of p53 protein is regulated by Mdm2/Proteasome degradation pathway. The regulation does not seem to be attributable to the change of proteasome activity. Increased Mdm2 expression in cells received high intensity of UVC suggests that the regulation might be controlled by Mdm2-mediated ubiquitination. The mechanism regulating the stability of p53 protein during UVC-induced apoptosis in SK-HEPl cells was discussed.

서지기타정보

서지기타정보
청구기호 {MBS 03023
형태사항 vi, 53 p. : 삽도 ; 26 cm
언어 한국어
일반주기 저자명의 영문표기 : So-Young Chung
지도교수의 한글표기 : 조철오
지도교수의 영문표기 : Cheol-O. Joe
학위논문 학위논문(석사) - 한국과학기술원 : 생물과학과,
서지주기 참고문헌 : p. 47-53
주제 p53 단백질
세포예정사
안정성
UVC
SK-HEPl 세포
p53
apoptosis
stability
UVC
SK-HEPl cells
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