서지주요정보
보조용매가 첨가된 초임계 이산화탄소를 이용한 탁솔과 바카틴 Ⅲ의 추출에 관한 연구 = Extraction of taxol and baccatin Ⅲ by using supercritical carbon dioxide mixed with various cosolvents
서명 / 저자 보조용매가 첨가된 초임계 이산화탄소를 이용한 탁솔과 바카틴 Ⅲ의 추출에 관한 연구 = Extraction of taxol and baccatin Ⅲ by using supercritical carbon dioxide mixed with various cosolvents / 신혜원.
저자명 신혜원 ; Shin, Hye-Won
발행사항 [대전 : 한국과학기술원, 1995].
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소장정보

등록번호

8005807

소장위치/청구기호

학술문화관(문화관) 보존서고

MCHE 95024

SMS전송

도서상태

이용가능

대출가능

반납예정일

초록정보

Taxol, a novel diterpenoid containing a taxane ring to exhibit significant activity against various leukemias and solid tumors, occurs as a very minor component in several species of Taxus. It was first isolated from the bark of the slow-growing yew tree, Taxus brevifolia, in 1971. The scarcity of taxol and the ecological impact of harvesting it have prompted extensive searches for alternative sources including semi-synthesis from baccatin III, total synthesis, cell culture production, but these methods are not only inefficient to produce taxol but also need to purify taxoid from solvents or biomass sources. The supercritical fluid extraction is a nondestructive method for isolating valuable constituents from natural materials. In this study, the extraction of taxol and baccatin III from the ground needles of Taxus cuspidata were carried out by using supercritical carbon dioxide with and without cosolvents such as ethyl acetate, methanol, ethanol, ether, acetonitrile, methylene chloride and tri-n-butyl phosphate at 40℃ and 300 bar. Taxol and baccatin III contents in the extracts were determined by HPLC. The highest yields of taxol and baccatin III could be obtained by the supercritical extraction with 3 wt% methanol and ethyl acetate, respectively, as cosolvents. It was also found that the selectivities of taxol and baccatin III were 0.117 and 1.245 wt \%. respectively, with 0.7 wt \% ethyl acetate. which it was demonstrated that the selectivities of taxol and baccatin III were increased about 5 and 52 times than those of conventional organic solvent extraction.

서지기타정보

서지기타정보
청구기호 {MCHE 95024
형태사항 viii, 77 p. : 삽도 ; 26 cm
언어 한국어
일반주기 저자명의 영문표기 : Hye-Won Shin
지도교수의 한글표기 : 이흔
지도교수의 영문표기 : Huen Lee
학위논문 학위논문(석사) - 한국과학기술원 : 화학공학과,
서지주기 참고문헌 : p. 72-77
주제 Extraction (Chemistry)
Solvents.
Supercritical fluid extraction.
추출. --과학기술용어시소러스
용매. --과학기술용어시소러스
초임계 추출
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