서지주요정보
특정 인돌 알칼로이드의 추출 및 합성 = Extraction and synthesis of specific indole alkaloids
서명 / 저자 특정 인돌 알칼로이드의 추출 및 합성 = Extraction and synthesis of specific indole alkaloids / 박상우.
저자명 박상우 ; Park, Sang-Woo
발행사항 [대전 : 한국과학기술원, 1993].
Online Access 원문보기 원문인쇄

소장정보

등록번호

8003869

소장위치/청구기호

학술문화관(문화관) 보존서고

MCHE 93017

휴대폰 전송

도서상태

이용가능

대출가능

반납예정일

초록정보

Vinca(Catharanthus roseus)produces the commercially important indole alkaloids as anticancer agents such as vinblastine and vincristine. Because of their extremely low concentrations, the cost to extract them from cultivated plants is high. Furthermore, their complicated chemical structures discourage chemical synthesis in respect to economic consideration. Vinblastine and vincristine are produced by coupling two different monomeric indole alkaloids, vindoline and catharanthine. The former is accumulated at a relatively high level in the plant, whereas the latter could be produced at considerable lel by plant tissue culture. Thus, it has been considered rational to produce the dimers by coupling vindoline extractable from cultivated plants and catharanthine available from plant tissue cultures. Vindoline was efficiently extracted from the leaves of cultivated plants at 35-70℃ and at 100-300 bar by SFE (supercritical fluid Extraction) using carbon dioxide. The highest vindoline selectivity(63%) out of the extract was obtained at 35℃ and at 100 bar. Catharanthine was chemically extracted from the hairy root cultures by two stage culture using sucrose and fructose. The monomeric precursors vindoline and catharahthine were coupled in the presence of a catalytically effective amount of ferric ion.

서지기타정보

서지기타정보
청구기호 {MCHE 93017
형태사항 [vi], 64 p. : 삽도 ; 26 cm
언어 한국어
일반주기 저자명의 영문표기 : Sang-Woo Park
지도교수의 한글표기 : 이흔
지도교수의 영문표기 : Huen Lee
학위논문 학위논문(석사) - 한국과학기술원 : 화학공학과,
서지주기 참고문헌 : p. 61-64
주제 Extraction (Chemistry)
Indole alkaloids.
추출. --과학기술용어시소러스
항종양성 항생물질. --과학기술용어시소러스
QR CODE qr code