In chapter 1, intermacromolecular complex formations between poly(L-proline) (PLP) having α-helical conformation and complementary macromolecules, such as poly (methacrylic acid)(PMAA) and poly(acrylic acid)(PAA) having random-coiled conformation, through hydrogen bonding in aqueous medium have been studied by viscosity measurement. And selective intermacromolecular complexation phenomea in ternary-component system involving macromolecules with different conformations, such as poly(L-proline)(PLP), poly(ethylene oxide)(PEO), and poly(methacrylic acid)(PMAA) has been studied by viscosity measurement. From the reduced viscosity change for the binary-component systems, the minimum points at [PLP]/[PMAA]=1.0 and [PLP]/[PAA]=1.0 suggest 1:1 complex formation, and for the ternary-component system it may be suggested that relative complexation ability of a helical PLP is greater than that of a random-coiled PEO with respective to a random-coiled PMAA.
In chapter 2, stability constants and thermodynamic parameters of (i.e. standard free energy change $\triangle{F}^\circ$, standard enthalpy change $\triangle{H}^\circ$, and standard entropy change $\triangle{S}^\circ$) have been determined for intermacromolecular complexation processes in binary-component systems composed of PLP, PVPo, PEO, PMAA, and PAA. Comparing these values in binary-component systems the selectivity of a particular macromolecule in multicomponent systems with respective to a complementary macromolecule was calculated. From these results it has been observed that the complexation ability is determined by the conformation of participating macro-molecules as well as the interacting strength of active sites.
지금까지 고분자 상호간의 선택적 복합체 형성에 관한 연구 방법으로써 주로 사용되어져왔던 정성적 방법과 처음으로 시도한 정량적 방법간에 있어서의 일치관계를 연구하였으며 또한 복합체를 형성하게하는 여러인자들과 복합체 형성시 나타나는 고분자의 구조 의존성에 관해서 연구를 하였다.
점성도 변화 방법을 이용한 정성적 방법으로부터의 결과가 잘 일치하고 있으며, 또한 정성적인 방법에 의해서는 삼성분계에만 적용해서 실험할 수 있었는데 반해 정량적인 방법에 의해서는 이성분계의 실험을 통해서 다성분계로의 적용이 용이함을 알 수 있었고 복합체 형성시에 영향을 미치는 인자로는 구조적인 요인과 형태적인 요인이 함께 작용함을 알 수 있었다.
