서지주요정보
Preparation, characterization, and application of metal oxide and metallic nanomaterials = 금속 산화물 및 금속 나노 물질의 합성, 특성화, 응용에 관한 연구
서명 / 저자 Preparation, characterization, and application of metal oxide and metallic nanomaterials = 금속 산화물 및 금속 나노 물질의 합성, 특성화, 응용에 관한 연구 / Won-Seok Seo.
저자명 Seo, Won-Seok ; 서원석
발행사항 [대전 : 한국과학기술원, 2003].
Online Access 원문보기 원문인쇄

소장정보

등록번호

8014656

소장위치/청구기호

학술문화관(문화관) 보존서고

DCH 03014

SMS전송

도서상태

이용가능

대출가능

반납예정일

초록정보

The first practical synthesis of Gelastatins, a natural product isolated from the culture broth of westerdykella multispora F 50733 found in soil sample in 1997, and Gelastatin-derived analogs have been studied. Gelastatins were found to exhibit impressive biological activities, including inhibition of Gelatinase A (MMP-2) and inhibition of tumor necrosis factor-$\alpha$ converting enzyme (TACE). Gelastins contain a characteristic dihydropyrane framework and a conjugated triene systems which consist of cis and trans configurations. Several approaches for the lactone ring system was attempted and total synthesis of Gelastatins was completed from Meldrum’s acid. Also, the design, synthesis and structure-activity relationship of a series of Gelastatin-derived analogs as inhibitors of the MMP-2 and TACE was studied. From the MMP-2 and TACE inhibition studies, it was concluded that lactone ring system and hydrophobic group of site III are essential for the substrate recognition by the enzyme. Based on the activities of Gelastatins and Gelastin-derived analogs, we suggested a new pharmacophore model. During the course of our studies on the synthesis of Gelastatins containing a key framework, dihydropyran ring, a new synthetic method constructing the valuable template and combinatorial libraries via ring closing metathesis, cross metathesis, and cycloaddition reaction was developed.

서지기타정보

서지기타정보
청구기호 {DCH 03014
형태사항 vi, 62 p. : 삽도 ; 26 cm
언어 영어
일반주기 저자명의 한글표기 : 서원석
지도교수의 영문표기 : Joon-Taik Park
지도교수의 한글표기 : 박준택
수록잡지명 : "Preparation and optical properties of highly crystalline, colloidal, and size-controlled indium oxide nanoparticles". Advanced materials, v.15 no.10 , pp.795-797 (2003)
수록잡지명 : "Osmium replica of mesoporous silicate MCM-48: efficient and reusable catalyst for oxidative cleavage and dihydroxylation reactions". Journal of the american chemical society, v.125 no.23, pp.6844-6845 (2003)
학위논문 학위논문(박사) - 한국과학기술원 : 화학과,
서지주기 Includes references
주제 Metal oxide
Nanomaterials
금속 산화물
나노 물질
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