서지주요정보
Synthesis and study on biological activity of quinoxalyl octadepsipeptide = 퀴녹살릴 옥타뎁시펩타이드의 합성 및 생체활성의 연구
서명 / 저자 Synthesis and study on biological activity of quinoxalyl octadepsipeptide = 퀴녹살릴 옥타뎁시펩타이드의 합성 및 생체활성의 연구 / Yun-Bong Kim.
저자명 Kim, Yun-Bong ; 김윤봉
발행사항 [대전 : 한국과학기술원, 2002].
Online Access 원문보기 원문인쇄

소장정보

등록번호

8012717

소장위치/청구기호

학술문화관(문화관) 보존서고

MCH 02005

SMS전송

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초록정보

Echinomycin is well known to natural product which shows strong antibiotic activity. Its outer quinoxaline rings have a important role of bis-intercalating around the DNA, and the $C_2$-symmetric peptide also has an interesting biological activity. Connection with the synthesis of echinomycin analogue, new quinoxaline antibiotics which have a cyclic octadepsipeptide but different inner bridge $(-CH_2-S-CH_2-S-CH_2-)$ havw been synthesized. $C_2$-symmetric cyclic octadepsipeptide have been prepared from tradepsipeptide, Cbz-D-Ser[H-Ala-MeCys(Bam)-Me-Val]-OPa, as a key intermediate. New quinoxalyl compounds (66 and 69) were prepared from 55 through 3 steps. Their oxidized forms (67, 68, 70 and 71) were also prepared by oxidation with m-CPBA or dimethyldioxirane. Cytotoxcities of YK-2000 - 2003 against human cancer cell were measured. The YK-2000(66) shows a similar cytotoxicity to echinomycin.

서지기타정보

서지기타정보
청구기호 {MCH 02005
형태사항 iii, 45 p. : 삽도 ; 26 cm
언어 영어
일반주기 저자명의 한글표기 : 김윤봉
지도교수의 영문표기 : Yong-Hae Kim
지도교수의 한글표기 : 김용해
학위논문 학위논문(석사) - 한국과학기술원 : 화학과,
서지주기 Reference : p. 43-45
주제 Echinomycin
anti-cancer activity
DNA intercalator
Octadepsipeptide
이치노마이신
항암특성
옥타뎁시펩타이드
인터킬레이터
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