서지주요정보
술폰화된 폴리에틸렌옥사이드가 그래프트된 폴리우레탄/폴리스티렌 IPN의 혈액적합성에 관한 연구 = Blood compatibility of sulfonated poly(ethylene oxide)-grafted polyurethane/polystyrene IPN
서명 / 저자 술폰화된 폴리에틸렌옥사이드가 그래프트된 폴리우레탄/폴리스티렌 IPN의 혈액적합성에 관한 연구 = Blood compatibility of sulfonated poly(ethylene oxide)-grafted polyurethane/polystyrene IPN / 윤여상.
저자명 윤여상 ; Yoon, Yeo-Sang
발행사항 [대전 : 한국과학기술원, 1999].
Online Access 원문보기 원문인쇄

소장정보

등록번호

8009430

소장위치/청구기호

학술문화관(문화관) 보존서고

MCHE 99023

SMS전송

도서상태

이용가능

대출가능

반납예정일

초록정보

Blood compatibility is the most important property required for biomedical materials. There are many basic concepts for development of blood compatible polymers. But it is known that the perfect nonthrombogenic materials have never been obtained. It may be difficult to regulate blood-materials interactions by simple molecular design of polymeric materials. The future trend is toward a combination of concepts and hybridization of artificial materials and biological molecules. Our research group has investigated the blood compatibility of PU/PS IPN with hydrophilic-hydrophobic microphase separated structure and PEO- grafted PU/PS IPN. In this study, the effect of incorporation of ions into PU/PS IPN on blood compatibility was investigated. The series of PU/PS IPN, PEO-grafted PU/PS IPN were synthesized and ionization was accomplished by quaternizing the tertiary amine of MDEA with (-propane sultone. Their physical, thermal and mechanical properties were examined by a number of different techniques such as SEM, AFM, DMTA, ESCA, ATR-IR, NMR, contact angle measurement, Instron tensile tester. The fractured surface and surface of PU/PS IPNs all exhibited microphase separated structures with dispersed PS domains in the continuous PU matrix. The PS domain size decreased with increasing MDEA and increasing the content of PEO side chains. PU/PS IPNs exhibited two transition temperatures, each corresponding to the component polymers due to the phase separated structure. Sulfonated PU/PS IPNs with ionic sulfonate group were more hydrophilic than the corresponding nonionized materials. PU/PS IPNs have an excellent mechanical property compared with PU and PS. In the blood compatibility test, the amount of platelets adsorbed, activated upon the PU/PS IPNs were reduced compared with PU and PS. Sulfonated PU/PS IPNs with ionic sulfonate group showed enhanced blood compatibility compared with the corresponding nonionized PU/PS IPNs due to synergistic effect of microphase separated structure, mobility of PEO side chains and negatively charged sulfonate groups.

서지기타정보

서지기타정보
청구기호 {MCHE 99023
형태사항 ix, 81 p. : 삽도 ; 26 cm
언어 한국어
일반주기 저자명의 영문표기 : Yeo-Sang Yoon
지도교수의 한글표기 : 김성철
지도교수의 영문표기 : Sung-Chul Kim
학위논문 학위논문(석사) - 한국과학기술원 : 화학공학과,
서지주기 참고문헌 : p. 79-81
주제 폴리우레탄/폴리스티렌 IPN
혈액적합성
미세상분리구조
술폰화된 폴리에틸렌옥사이드 그라프팅
Polyurethane/polystyrene IPN
Blood compatibility
Microphase separated structure
Sulfonated poly(ethylene oxide) 그라프팅
QR CODE qr code