Base Isolation System is an effective design strategy that provides a practical substitute for the seismic design of bridge. The role of base isolator under seismic loading is to isolate the bridge from the horizontal components of the earthquake ground movement, while the vertical components are transmitted through to the bridge relatively unchanged. In this study, two basic application strategies are suggested. For the constructed bridges, the reinforcement of main structure will be minimized by the application of the sliding isolation system with the optimum design of coefficient of friction and bearing displacement. And for the bridges to be constructed achieving lower cost of building and more safety margin will be the goal of this study by reducing earthquake load by dissipating energy and distributing the earthquake load to every pier of the bridge. In this paper, new base isolation system is suggested for bridge. It consists of PTFE(Poly-Tetra-Flour-Ethylene) friction bearing as damping and vertical load resisting device and LRB(Laminated Rubber Bearing) as restoring force device. Experimental tests and theoretical analysis were conducted to examine the functional capabilities of device. The shaking table test results show that the deck acceleration and pier shear force of the bridge isolated by base isolation system are significantly reduced. And the numerical analysis by employing an approximate bi-linear friction model can resonably simulate the earthquake responses of the base isolation systems compared with shaking table test.