서지주요정보
F9 세포 분화과정에서의 gap junctional intercellular communication의 조절 = Regulation of gap junctional intercellular communication during differentiation in F9 cells
서명 / 저자 F9 세포 분화과정에서의 gap junctional intercellular communication의 조절 = Regulation of gap junctional intercellular communication during differentiation in F9 cells / 조수진.
저자명 조수진 ; Cho, Su-Jin
발행사항 [대전 : 한국과학기술원, 1996].
Online Access 원문보기 원문인쇄

소장정보

등록번호

8006723

소장위치/청구기호

학술문화관(문화관) 보존서고

MBS 96027

SMS전송

도서상태

이용가능

대출가능

반납예정일

초록정보

Gap junctional intercellular communication(GJIC) provides a mechanism for regulating multicellular activities by allowing the exchange of small diffusible signaling molecules between neighboring cells. This study was conducted to assess the GJIC during the differentiaion of F9 cells. F9 cells derived from mouse embryonic teratocarcinoma were stimulate to differentiate to visceral or parietal endoderm by retinoic acid and by retinoic acid and dibutyryl cyclic AMP, respectively. The differentiation states of F9 cells were monitored by the cell morphology and by the expression level of collagen type Ⅳ(α_2). When GJIC was assessed by measuring the transfer of scrape-loaded lucifer yellow dye, differentiated cells showed decreased communication as compared with undifferentiated cells. Northern blot analysis revealed the decrease of the connexin 43 transcript during the both differentiation processes. Western blot analysis also showed that the cellular amount of connexin 43 protein was decreased as F9 cells differentiated to parietal endoderm or visceral endoderm. Data suggest a constitutive disruption of connexin 43 during chemical induced differentiation in F9 cells.

서지기타정보

서지기타정보
청구기호 {MBS 96027
형태사항 vi, 40 p. : 삽도 ; 26 cm
언어 한국어
일반주기 저자명의 영문표기 : Su-Jin Cho
지도교수의 한글표기 : 조철오
지도교수의 영문표기 : Cheol-O Joe
학위논문 학위논문(석사) - 한국과학기술원 : 생물과학과,
서지주기 참고문헌 : p. 35-40
주제 간극 연접 인자
분화
세포간 대화
Gap Junction
F9 cell
Differentiation
Parietal Endoderm
Visceral Endoderm
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