서지주요정보
Synthesis and study of antitumor activity for poly-L-cysteine attached cyclophosphamide = 폴리-L-시스테인에 결합된 사이클로포스파마이드의 합성과 항암효과에 관한 연구
서명 / 저자 Synthesis and study of antitumor activity for poly-L-cysteine attached cyclophosphamide = 폴리-L-시스테인에 결합된 사이클로포스파마이드의 합성과 항암효과에 관한 연구 / Jeong-Hun Sohn.
저자명 Sohn, Jeong-Hun ; 손정훈
발행사항 [대전 : 한국과학기술원, 1996].
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소장정보

등록번호

8006756

소장위치/청구기호

학술문화관(문화관) 보존서고

MCH 96011

SMS전송

도서상태

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초록정보

As a delivery system of cyclophosphamide(CP), 4-(poly-L-cysteine)cyclophosphamide(1) was synthesized. It has a drug loading of 28.3 mol% and average molecular weight($\mbox{\overline{Mn}}$) is 4274. The hydrolytic kinetics of 1 using $^{31}P$ NMR in 1 M lutidine buffer at pH 7.4, 37 ℃ showed first order reaction rate which gave half-life of 45 min, and showed that 4-hydroxycyclophosphamide(2) and aldophosphamide(3)/aldophosphamide hydrate(5)/thiohemiacetal(27) were appeared nearly at the same time. Also the kinetics exhibited that 1, 2, 3/5/27 were not equilibrated and the signal of 1 was being decreased and that of 3/5/27 was being increased till 70 min. After 2 increased until 40 min it stayed nearly constant and phosphoramide mustard(4) was not observed by 70 min. Based on the $\mbox{reports}^{38,39}$ these data were consistent with the facts that the signal of 3/5/27 contained mainly 27 and the rate of appearance of 27 was fast relative to the rate for 1. Thus this implicates that AP(3) to produce ultimate alkylating agent PM(4) exists in small amount. In vivo antitumor activity of 1 showed less T/C value than that of free CP and thus did not exhibited a promise for therapeutic effectiveness. However, these results could derive that 1 had abilities for delivery of 4-hydroxycyclophosphamide(2) and slow release of aldophosphamide(3) and that sulfhydryl in 1 might result in a decrease of cytocidal effect of parent drug.

서지기타정보

서지기타정보
청구기호 {MCH 96011
형태사항 ii, 44 p. : 삽도 ; 26 cm
언어 영어
일반주기 저자명의 한글표기 : 손정훈
지도교수의 영문표기 : Young-H. Chang
지도교수의 한글표기 : 장영환
학위논문 학위논문(석사) - 한국과학기술원 : 화학과,
서지주기 Reference : p. 41-44
주제 Cyclophosphamide
poly-L-cysteine
CP Delivery System
사이클로포스파마이드
폴리-L-시스테인
CP 전달 체계
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