서지주요정보
간극연접을 통한 세포간 대화에 미치는 인삼 추출물 ginsenoside $Rh_2$의 영향 = Effect of ginsenoside $Rh_2$ on cell-to-cell communication
서명 / 저자 간극연접을 통한 세포간 대화에 미치는 인삼 추출물 ginsenoside $Rh_2$의 영향 = Effect of ginsenoside $Rh_2$ on cell-to-cell communication / 박경미.
저자명 박경미 ; Park, Kyeong-Mee
발행사항 [대전 : 한국과학기술원, 1998].
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등록번호

8008473

소장위치/청구기호

학술문화관(문화관) 보존서고

MBS 98001

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초록정보

Effects of ginsenosides from Panax ginseng C. A. Meyer on gap junctional intercellular communication were investigated. Ginsenoside $Rh_2$ drastically inhibited a PMA-induced closure of gap junction channel of clone 9 cells while other ginsenosides had no effects. As the phosphorylation states of connexin43 were revealed by Western blotting analysis, connexin43 proteins were evenly distributed among connexin43-NP, -$P_1$, -$P_2$ in the subconfluent cultures whereas connexin43-NP was mainly expressed in the confluent cultures of clone 9 cells. When ginsenoside $Rh_2$ was treated in the subconfluent cultures, connexin43-$P_2$ was increased with concomittent decreases of connexin43-NP and connexin43-$P_1$. In the confluent cultures, ginsenoside $Rh_2$ strongly increased connexin43-$P_2$ which is barely detected in the normal cells. With the presence of PMA, a well-known tumor promoter, connexin43-$P_2$ was increased with a total expense of connexin43-NP and connexin43-$P_1$ in the subconfluent cultures while connexin43-$P_2$ was strongly increased with a slight decrease of connexin43-NP in the confluent cultures. However, the pretreatment of ginsenoside $Rh-2$ did not affect the PMA-induced phosphorylation of connexin43 either in the subconfluent or confluent cultures. The inhibitory effect of ginsenoside $Rh_2$ on the PMA-induced disruption of gap junctional intercellular communication is not seemed to be mediated by protein kinase C signaling pathway.

서지기타정보

서지기타정보
청구기호 {MBS 98001
형태사항 v, 34 p. : 삽도 ; 26 cm
언어 한국어
일반주기 저자명의 영문표기 : Kyeong-Mee Park
지도교수의 한글표기 : 조철오
지도교수의 영문표기 : Cheol-O Joe
학위논문 학위논문(석사) - 한국과학기술원 : 생물과학과,
서지주기 참고문헌 : p. 27-32
주제 간극연접
커넥신43
인삼
인산화
인산화효소 C
Gap junction
Connexin43
Ginseng
Phosphorylation
PKC
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