When Fe atoms at concentrations above 7.5 wt.% of the specimen are added to the sintered 90Mo-10Ni specimen at $1540^\circ{C}$ and the specimen is heat-treated at the same temperature, chemically induced recrystallization (CIR) occurs. In this case, Fe atoms produce tensile misfit in the Mo-Ni solid grain surface. W atoms, which produce compressive misfit in the Mo-Ni solid grain surface, are added simultaneously with 7.5 wt% Fe atoms at the specimen. The misfit decreases while the chemical free energy increases from the center to the surface of the specimen since diffusion of W in the liquid is slower than that of Fe. In this specimen CIR occurs only at the center with high misfit, while only chemically induced interface migration (CIIM) occurs near the specimen surface with low misfit but with large chemical free energy than center. From this result, the misfit in the diffusion layer is thus shown to be a principal cause to induce the CIR.